Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

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Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.

Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell buffy coat. Both sample types are used in DNA methylation studies. Cell types have unique methylation patterns and processing can impact cell distr...

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Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review studies that have assessed DNA methylation in cord blood following maternal expo...

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ژورنال

عنوان ژورنال: Epigenetics

سال: 2018

ISSN: 1559-2294,1559-2308

DOI: 10.1080/15592294.2017.1417710